https://devzone.nordicsemi.com/f/nordic-q-a/121853/two-twi-instance-in-nrf52810SDK: nRF5 SDK Board: nRF52810 Softdevice: S112 Hi, I have a board that has two TWI lines, one has two peripherals and the other has one peripheral connected to nrf52810. Is it possible to create two twi instance to use the following. Also isen-USTelligent Community 13Wed, 28 May 2025 12:48:55 GMThttps://devzone.nordicsemi.com/thread/537364?ContentTypeID=1Wed, 28 May 2025 12:48:55 GMT137ad170-7792-4731-bb38-c0d22fbe4515:1d37bccd-62bf-4667-bc8c-a4ee908f0208Vidar Berg<p>Hi,</p> <p>the nRF52810&nbsp;does not have multiple TWIM instances in HW. This means you cannot communicate on different buses concurrently. However, you can uninitialize and reinitialize TWIM0 if you need to change the pinout at runtime.</p> <p><img style="font-family:inherit;max-height:240px;max-width:320px;" src="https://devzone.nordicsemi.com/resized-image/__size/640x480/__key/communityserver-discussions-components-files/4/pastedimage1748436371967v1.png" alt=" " /></p> <p>Ref.&nbsp;<a href="https://docs.nordicsemi.com/bundle/ps_nrf52810/page/memory.html">Memory</a></p> <p>Best regards,</p> <p>Vidar</p><div style="clear:both;"></div>