https://devzone.nordicsemi.com/f/nordic-q-a/55963/nrf52832-irq-issueirq init as below: I use port event, and muti-gpio irqs. Irq gpio connect a sensor`s irq pin. I detect irq gpio level in irq_Handler(), high level is my need, the low level, not my need, would return. Irq gpio I config not pull, no irq generateen-USTelligent Community 13Mon, 06 Jan 2020 16:29:53 GMThttps://devzone.nordicsemi.com/thread/227758?ContentTypeID=1Mon, 06 Jan 2020 16:29:53 GMT137ad170-7792-4731-bb38-c0d22fbe4515:b90704e8-cd2e-4172-954b-2f6cf71f0bebStian R&#248;ed Hafskjold<p>I&#39;m not sure if I understand the problem here. What do you mean with &quot;device bootup&quot;? Is that the nRF52 or the sensor booting up? Typically you would wait to configure the GPIOTE on the nRF52 until the sensor has booted up and is ready to send signals.</p> <p>If you want the signal to be stable, and not floating, while the sensor is turned off, you will need a pull down resistor, either internal or external.</p><div style="clear:both;"></div>