https://devzone.nordicsemi.com/f/nordic-q-a/58173/how-to-read-out-saadc-values-with-multiple-channel-enabledHi Devzone: I have 1 differential pair and 1 single ended pin I want to read, so I wrote code below into saadc_init function: In this case AIN4 is the single ended pin and AIN2 and AIN3 are the differential pair . I&#39;m not quite sure how to geten-USTelligent Community 13Mon, 24 Feb 2020 11:29:54 GMThttps://devzone.nordicsemi.com/thread/235932?ContentTypeID=1Mon, 24 Feb 2020 11:29:54 GMT137ad170-7792-4731-bb38-c0d22fbe4515:cf0b39e1-2777-4d66-9aa9-be641886309fJ&#248;rgen Holmefjord<p>Hi,</p> <p>1. Both single-ended and differential sampling will generate a single sample per channel (single-ended is internally differential mode with the negative input connected to GND). You should set it to a multiple of the number of enabled channels. If you want to get the callback after the two channels have been sampled once, you should set the <span>SAMPLES_IN_BUFFER define</span>&nbsp;to 2.</p> <p>2. This depends on what channel you have used for each of the configs. If you used the single-ended config for channel 0, the sample for this will be in&nbsp;<span>p_buffer[0]. The samples are stored in the buffer as described in the <a href="https://infocenter.nordicsemi.com/topic/com.nordic.infocenter.nrf52832.ps.v1.1/saadc.html#saadc_operationmodes_scan">SAADC peripheral documentation</a>.</span></p> <p><span>Best regards,<br />Jørgen</span></p><div style="clear:both;"></div>