https://devzone.nordicsemi.com/f/nordic-q-a/67279/nrf52840-can-any-pin-be-configured-for-i2c-spiHi, we are moving from nRF52840 DK to integrate nRF52840 to our solution. In the datasheet for pin assignments ( Link ) it states &quot;recommendation usage; Standard drive, low frequency I/O only&quot; Does that mean that this Pin is not recommended to be configureden-USTelligent Community 13Fri, 16 Oct 2020 07:15:58 GMThttps://devzone.nordicsemi.com/thread/275253?ContentTypeID=1Fri, 16 Oct 2020 07:15:58 GMT137ad170-7792-4731-bb38-c0d22fbe4515:1bca69db-c2e3-4a87-a4dc-2acca2cdba08Oivind Nielsen<p>Up to 10kHz is considered low frequency.</p> <p>It is not recommended to use high drive or high frequency for those pins because&nbsp;doing so may cause interference issues for the radio.</p> <p>So the pins themselves can be configured for I2C or SPI, but it may cause other issues for you. I would recommend using different pins if it&#39;s possible.</p><div style="clear:both;"></div>