https://devzone.nordicsemi.com/f/nordic-q-a/71426/how-to-use-i2c1-of-nrf5340I didn&#39;t change nrf5340_cpuapp_common.dts, and I saw the macro definition of &quot;i2c1&quot; in &quot;devicetree_unfixed.h,&quot; but I called device_get_binding (DT_LABEL (DT_NODELABEL (i2c1)) and did return NULLen-USTelligent Community 13Mon, 08 Feb 2021 15:06:21 GMThttps://devzone.nordicsemi.com/thread/293380?ContentTypeID=1Mon, 08 Feb 2021 15:06:21 GMT137ad170-7792-4731-bb38-c0d22fbe4515:c71d431f-ecc3-4c2a-a1ec-df487ae01154Simon<p>Try setting&nbsp;<span>CONFIG_I2C</span><span>=y in prj.conf. Then it should work. I just tested it.&nbsp;</span><span>It is not enought to enable I2C in dts (hardware), you have to enable the software part/drivers as well.</span></p> <p><span>Best regards,</span></p> <p><span>Simon</span></p><div style="clear:both;"></div>