https://devzone.nordicsemi.com/f/nordic-q-a/73134/low-accuracy-gpio-pins-interrupt-control-system-wake-up-mechanismBoard: nRF51-DK (nRF51422 chip) SDK: 12.3.0 SoftDevice: S130 Compilation settings Optimization level O1 Debug information generated First GPIO pin is mapped to Button 1 (not shown in code) to wake up from SYSTEM OFF state. Second GPIOen-USTelligent Community 13Fri, 26 Mar 2021 14:38:58 GMThttps://devzone.nordicsemi.com/thread/302171?ContentTypeID=1Fri, 26 Mar 2021 14:38:58 GMT137ad170-7792-4731-bb38-c0d22fbe4515:6b228d74-73a8-4d00-bc13-d358d56a4a04run_ar<p>a. You can configure the pin polarity to toggle: <span style="font-family:monospace;font-size:11.6667px;left:533.473px;top:806.725px;"> Event mode: Generate</span><span style="font-family:monospace;font-size:11.6667px;left:533.473px;top:820.725px;">IN[n] when any change on pin.</span></p> <p>b. If I remember correctly you do not need to clear the interrupt. but you need to clear the event that triggered the interrupt.</p> <p>c. Yes, I think this should be fine.</p> <p>d. See: <span><a title="Usage" href="https://infocenter.nordicsemi.com/topic/com.nordic.infocenter.sdk5.v12.3.0/hardware_driver_gpiote.html?cp=7_5_9_2_5_4_1#gpiote_in_usage">Usage</a></span></p> <p>e. I am sure if will &quot;disable&quot; the wakeup while in system on. In system off. if the pin is configured correctly in detect mode, I think it will wake up/reset regardless.</p> <p>f. In system on you will be woken by an interrupt or event. In system off you will be woken by the gpio in <a href="https://infocenter.nordicsemi.com/pdf/nRF51_RM_v3.0.1.pdf?cp=5_2_0#%5B%7B%22num%22%3A570%2C%22gen%22%3A0%7D%2C%7B%22name%22%3A%22XYZ%22%7D%2C56.692%2C439.292%2Cnull%5D">detect mode</a></p><div style="clear:both;"></div>