https://devzone.nordicsemi.com/f/nordic-q-a/81399/nrf52840-v1-vs-v2-twim-pins-leak-consumption-migitationHi, I have a circuit with an I2C peripheral on a separate power switch. There is excessive power consumption (about 50&#181;A extra) due to leakage after TWIM is disabled and the power switch is off. On 52840v1, this code eliminated the leak: But on 52840v2en-USTelligent Community 13Thu, 04 Nov 2021 12:57:51 GMThttps://devzone.nordicsemi.com/thread/337478?ContentTypeID=1Thu, 04 Nov 2021 12:57:51 GMT137ad170-7792-4731-bb38-c0d22fbe4515:c21a29b6-a13c-4796-8032-4a648b650be9plotkin1996<p>It turns out that replacing nrfx_twim_enable/disable (which is useless, as driver runs it for every transaction internally) with pm_device_state_set did the trick. Still something to be wary about, as behavior is different between hardware releases.</p><div style="clear:both;"></div>