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LSByte first in radio payload field?

Reading the nRF51 RM. On page 82 there is this:

a

But it doesn't make sense to me to talk about the LSByte of the PAYLOAD field, as it's just arbitrary data, and the Radio specs are agnostic of what is in it.

So what does this actually mean? Will I have to reorder bytes or bits when I specify payload data that is to be used in Bluetooth protocol?

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