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nrf51822 wired UART and USB to UART

Hi, I have some question about wiredUART and USB to UART

I'm using nrf51822+BLE400.

Is there any difference UART communication between using USB to UART

and wiring on the UART pins?

I'm using ble_app_uart(SDK 12).

I'm asking because USB to UART port works fine but directly wired UART is not working.

It didn't receive datas from UART.

Should I use only one way for UART communication?

Should I change code to receive data from directly connected UART?

Thanks.

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