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Is there any relation between connection parameters and occasionally disconnection

I have a system, with cc2540 as central and n51822 as peripheral with s130. Sometimes while they are close to each other, the connection link gets lost. I disabled updating the connection parameters on the client(cc2540), and I set them just on peripheral. Is it acceptable or not? Where I can find best practices/settings on these parameters while I need to get fast feedback on getting out from the RSSI range and also need to do as much as fast on reconnecting;

Could you please clarify me with the impression of these parameters on my occasional disconnection problem?

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