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Mesh architecture for Generic On/Off servers - multiple subscription groups vs single group with node models grouped by app keys

First of all, thank you and kudos to Nordic Support Team for having an awesome and functional forum. 

Having said that, I have a question related to the architecture of mesh network in lighting application. What's the difference between having multiple groups and a single group that is fragmented using app keys ? For example, having different nodes subscribing to different groups (rooms, hallways, public toilets etc) based on their location in building vs. all nodes subscribing to one single group(whole building) but the node models are bound to different app keys based on their location in building ( for example, app key #1 for nodes in rooms, app key #2 for nodes in hallways etc)