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SDK_CONFIG file clarification NRF52

Hi All, 

I am using NRF5 SDK 17, I have been playing with several examples and noticed that when it comes set up, a peripheral or a priority or clock source there will always be two macro definitions for each one. with similar prefix: NRF and NRFX

for instance:

NRF_CLOCK_ENABLED 

and 

NRFX_CLOCK_ENABLED

What is the difference bettwen the two definitions ? 

Which one should I rely on when it comes to set up peripherals and/or priorities ? 

Thanks :) 

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