Is it possible to use internal pull-up/pull-down resistors with I2C, UART, etc?

I need pull-up/pull-down resistors on my UART and I2C lines and am wondering if I can enable the pull-up/pull-down resistors instead.  If this possible?  I can see how to configure them for GPIO, but I'm wondering if I use the same approach if it would interfere with the UART/I2C drivers.  Thanks

Other info:
nRF52480

nRF Connect SDK v2.1.0

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