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nRF52 GPIO near radio

Greetings. Could you provide more information on the issues with GPIO located near the radio in the nRF52 (PS 18.2.1)? Specifically, what is considered "high frequency digital I/O with large sink/source current." Are situations that are high frequency and low current fine? At what point should we start worrying?

For example, would an 8MHz SPI clock cause an issue? What about a 1kHz 5mA pulse?

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