4-bit SPI and QSPI

Maybe my question is trivial but I'm a little confused about the classification and the differences of serial interfaces like 4-bit SPI, QPI, QSPI... In my case I want interface an FTDI to the nRF52840 via SPI and I found the FT220XQ which is a USB Full Speed to 4-Bit SPI and the FT4222HQ which is a USB High Speed to QuadSPI or QSPI. Can the nRF52840 comunicate as 4-Bit SPI using the QSPI peripheral? Are these two interface compatible?

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