nRF9160 closes with `RPC_IP_ERR_NOT_CONN` reason during MQTT datamode upload

I am using the nRF9160 to upload a large set of data in chunk of 16kB in MQTT datamode. I am using the v2.6.1 SDK and toolchain. During the MQTT upload the connection seems to close due to an RPC_IP_ERR_NOT_CONN error. I cannot find any documentation on this error or trace back to where or why this occurs. This seems to occur at random times during the upload, but seldom occurs during shorter uploads. 

Here is the log 

[00:11:18.353,454] <inf> slm_at_host: Exit datamode
[00:11:20.024,719] <inf> nrf_modem: RPC_IP_CLOSED_NTF fd 0x0
[00:11:20.031,005] <inf> nrf_modem: Close reason RPC_IP_ERR_NOT_CONN
[00:11:20.039,001] <inf> nrf_modem: recv() fd 0x0, buf 0x2001bbdd, len 2, flags 0x40 (non-block)
[00:11:20.048,889] <err> net_mqtt_rx: [CID 0x20018228]: Connection closed.
[00:11:20.056,823] <inf> net_mqtt_sock_tls: Closing socket 0
[00:11:20.063,537] <inf> nrf_modem: close() fd 0x0
[00:11:20.070,312] <inf> nrf_modem: RPC_IP_CLOSE_RES fd 0x0, result RPC_IP_ERR_OK
[00:11:20.079,193] <err> slm_mqtt: ERROR: mqtt_input -128
[00:11:20.085,510] <inf> slm_mqtt: MQTT thread terminated
[00:11:41.184,387] <err> slm_at_host: AT command buffer overflow, 9588 dropped
[00:12:02.831,420] <err> slm_at_host: AT command buffer overflow, 16021 dropped
[00:12:24.480,255] <err> slm_at_host: AT command buffer overflow, 16021 dropped
[00:12:46.127,807] <err> slm_at_host: AT command buffer overflow, 16021 dropped
[00:13:07.776,062] <err> slm_at_host: AT command buffer overflow, 16021 dropped
[00:13:29.423,645] <err> slm_at_host: AT command buffer overflow, 16021 dropped
[00:13:54.020,538] <inf> slm: Power off triggered.
ASSERTION FAIL [!arch_is_in_isr()] @ WEST_TOPDIR/zephyr/kernel/mutex.c:110
        mutexes cannot be used inside ISRs
[00:13:54.036,010] <err> os: r0/a1:  0x00000004  r1/a2:  0x0000006e  r2/a3:  0x00000000
[00:13:54.044,677] <err> os: r3/a4:  0x200184c8 r12/ip:  0x00044257 r14/lr:  0x0003748f
[00:13:54.053,344] <err> os:  xpsr:  0x41000041
[00:13:54.058,532] <err> os: Faulting instruction address (r15/pc): 0x00043b54
[00:13:54.066,436] <err> os: >>> ZEPHYR FATAL ERROR 4: Kernel panic on CPU 0
[00:13:54.074,127] <err> os: Fault during interrupt handling

[00:13:54.080,566] <err> os: Current thread: 0x20017d90 (idle)

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