GPIO base addresses different for S (sense) and NS (no sense)

The last years I have developed a lot software (low level) for the nRF52840. I like this MCU very much, especially the SHORTS-Registers and EasyDMA are powerful for real short latency time with the peripherals. 

I do not like the RTOS. I have (a lot) Arduino Nano BLE 33 Sense with MbedOS, trying to bypass the OS wherever possible. I just finished a project for audio analysis with a lot of digital filters (mixed low pass and band pass) running in the background on the interrupt of the PDM-periphery (20 kHz scanning frequency). There is some jitter which may be caused by the OS.

Now I want to switch to the Seeed XIAO nRF54L15 Sense for 2 reasons: 1. the higher speed which would allow to double my number of filters and 2. the possibility to avoid the RTOS (https://github.com/lolren/nrf54-arduino-core).

I started the evaluation with the GPIOs (I use them with direct register access to measure the timing of interrupt handlers) and I have problems to understand the documentation. While it is very clear for the 52840, there are two base addresses for the ports of the 54L15, S for sense and NS for no sense. Why? If i read the description correct, this selection is done via the CNF-Registers. And which is the correct base address? (I will use NS, but that points to 0x4....... and from 52840 I expect 0x5.......).

Surely it is easy for the Nordic experts to explain these two base addresses for the GPIO ports. Thanks in advance ...

Update: Though the AI answer is really helpful, I will post this question anyway. Because otherwise this forum does not make any sense, it will be empty if the AI has learned enough. Hopefully the AI answer is published here.

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