Is it possible to use an external PA/LNA without a soft device( say using Zephyr RTOS)

We propose to use the SKY66112_11_203225L, but would also prefer to use Zephyr ( Or some other RTOS, like mynewt). I am aware of how to use the softdevice, but since neither RTOS uses the softdevice, how would I monitor the TX/RX switch, and thus drive the PA/LNA appropriately ?