eDRX / PSM mode always on?

So I have a question about the nRF9160 when enabling the xDRX or PSM mode. Does one just turn the option on and leave it on eaven while uploading data or do you turn it off each time you want to send some data and communicate with a socket?

lte_lc_psm_req( );
lte_lc_edrx_req( );

And do you need to request it again after sending data?