This is a bug report for SDK v15.3.
Once a GPIOTE interrupt is enabled for a pin, nrfx_gpiote_in_event_enable(pin, false) will not disable it. This appears to be an issue in nrfx_gpiote.c. Modifying the function as follows resolves the issue:
void nrfx_gpiote_in_event_enable(nrfx_gpiote_pin_t pin, bool int_enable) { NRFX_ASSERT(pin < NUMBER_OF_PINS); NRFX_ASSERT(pin_in_use_by_gpiote(pin)); if (pin_in_use_by_port(pin)) { uint8_t pin_and_sense = (uint8_t) m_cb.port_handlers_pins[channel_port_get(pin) - GPIOTE_CH_NUM]; nrf_gpiote_polarity_t polarity = (nrf_gpiote_polarity_t)(pin_and_sense >> SENSE_FIELD_POS); nrf_gpio_pin_sense_t sense; if (polarity == NRF_GPIOTE_POLARITY_TOGGLE) { /* read current pin state and set for next sense to oposit */ sense = (nrf_gpio_pin_read(pin)) ? NRF_GPIO_PIN_SENSE_LOW : NRF_GPIO_PIN_SENSE_HIGH; } else { sense = (polarity == NRF_GPIOTE_POLARITY_LOTOHI) ? NRF_GPIO_PIN_SENSE_HIGH : NRF_GPIO_PIN_SENSE_LOW; } nrf_gpio_cfg_sense_set(pin, sense); } else if (pin_in_use_by_te(pin)) { int32_t channel = (int32_t)channel_port_get(pin); nrf_gpiote_events_t event = TE_IDX_TO_EVENT_ADDR((uint32_t)channel); nrf_gpiote_event_enable((uint32_t)channel); nrf_gpiote_event_clear(event); if (int_enable) { nrfx_gpiote_evt_handler_t handler = channel_handler_get((uint32_t)channel_port_get(pin)); // Enable the interrupt only if event handler was provided. if (handler) { nrf_gpiote_int_enable(1 << channel); } } // BEGIN BUGFIX else { nrf_gpiote_int_disable(1 << channel); } // END BUGFIX } }