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nRF52840 working voltage

nRF52840 works with 1.8V supply voltage? We are using Circuit configuration number.5. it tells VDD should connect to VDDH.

As per the circuit configuration 5: VDDH is N/A. We should worry only about VDD rail, as per spec it is 1.7–3.6 V. We are planning to operate with 1.8V. Do you foresee any issues?

 In case if we don’t want to use USB power/ interface as per configuration 5 , Can we leave VBUS pin open or connect it to GND. nRF52840 works only with VDD rail?