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Ground splitting for Custom PCB with two transceivers

Hello expert,

I would like to design a custom PCB that has two transceivers on it. One transceiver is working as a beacon/continuous wave generator (TX) and the other one works as a continuous receiver (RX) and sometimes as a BLE slave. I would like to use 52833 as the receiver and haven't decided which chipset for the transmitter yet.

I have a question regarding the possible PCB design. I think I would do a 4-layer board design with relatively compact component placement.  If you regard the two modules as a whole, it's like a full-duplex system. Self-interference leakage from TX to RX seemed can not be totally avoided. Whatmore, I would like to add some SPI and I2C peripheral sensors which may also cause interference to my RX on a compact design. Will it be helpful to eliminate these issues if I split the digital ground, TX ground, and RX ground as well as TX/RX power plane?

Could anyone give me some suggestions on the ground/power design strategy?

Thank you so much!

Best regards,

Lynn Z

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