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Bootloader/ DFU options over serial (UART, USB)

Hi,

I have following questions with reference to two different bootloader scenarios with my custom nRF52833 board: 

1) UART based: do I absolutely need RTS, CTS for this or just TX, RX will do?

2) Can the native USB port (i.e in nRF52833-DK context - using J3 and Not Interface MCU USB Connector J2)
     be used as bootloader interface?
     As I understand, when we use nrfutil dfu usb-serial command, we still need to pick COM port
   (created by CDC ACM).

Please advise. Thanks.

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