nRF52810 don't work normally

Hi,

I have a strange problem.

When I connect the jlink and battery power on board at the same time,and download the application, it works normally. But when I disconnect the jlink, and connect the battery power along, it seems working unusually.After I reset(connect the P0.21 to ground) the board, it will works normally.

UNUSUAL STATUS: It doesn't unwork completely,  only all my interruptions defined don't work. 

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