The poly1305 implementation is only covering the obsolete RFC 7539 which got updated by RFC 8439
https://github.com/nrfconnect/sdk-nrfxlib/blob/main/crypto/nrf_oberon/include/ocrypto_poly1305.h#L21
Especially when using the poly1305 mac algorithm, the nrfxlib implementation is failing the official test vectors.