Custom nRF9160 Board can load, but does not appear to be running

I had been working with a DK and a Circuit Dojo - nRF9160 Feather https://github.com/circuitdojo/nrf9160-feather just to get my basic hardware working. I just had custom boards made for our first pre-production hardware but I cannot get it talking using the serial_lte_modem example at all, using the same hex file, same RX and TX pins on the nRF9160 and ESP32 basically nothing has changed other than trying to transfer things to our own board instead of evaluation boards.

Here is the schematic for the nRF9160 hookup, everything loads fine form the DK to the nRF9160 but doesn't want to respond to anything sent over the serial port. 

https://i.imgur.com/23LeGKg.png

GPS sub-sheet:



LTE-ANT sub-sheet:

Sim sub-sheet: 

I also tried to create a custom board definition but it doesn't want to work either: https://www.dropbox.com/s/o87fcq1u89i85fq/custom_nrf9160.zip?dl=0

I am really at a loss to why this isn't working when it worked on the other boards.

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