Driving D+ or D- when VBUS is not powered

HI,

We are looking to multiplex a few I/O on the NRF52840 to save pin count on a header.  If D+ or D- get driven when VBUS is unpowered, will that damage the NRF52840? Or if D+ is driven to VCC when VBUS is unpowered will it be not damaged? 

Thanks,

Ed

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