In connection with a nRF51422 evaluation kit, I installed the Keil development tool in a non default path then subsequent installation of nrf51_sdk_v4_3_0_27417 produced a non functional tool-chain. Keil was unable to find the proper profile for the nRF51422 processor.
My guess is that "nrf51_sdk_v4_3_0_27417" is assuming Keil to be at the default location, despite that there seems to be no error message during installation of the SDK nor notes in the manual.
Re-installation using default location of Keil (and nrf51_sdk_v4_3_0_27417) solved this issue