SW device "no target connected " nRF52840

Hello

Im developping in nrf52840 , and created a pcb using nrf52840 qiaa 7x7

configuration

are we need to do something to first time?

because im trying to program but keil shows this 

i have no idea if need to charge a bootloader something like that, we are checking the circuit connections 

but we would like to konw if need to do  to the first time using nrf52840 qiaa 7x7 

thanks and regards

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