I have an nRF52840 design that uses I2C to communicate with a SGTL5000 CODEC as well as a U-blox SAM8 module. Once MCLK on the I2S is turned on and running, if I try and talk to the SAM-8 module, the I2C bus will lock up and require a power cycle to reset. This is never an issue without the MCLK running and if I turn off the MCLK, talk to the SAM-8 and then turn the MCLK back on it also works. It's a workaround, but causes all kinds of clicks and pops on my audio so not a good one. The 2 interfaces are not related, so the correlation is a bit odd, but repeatable.