I have three nRF5340 Audio boards (PCA10121, 1.0.0). Most of the times, nrfjprog --com won't detect VCOMs on these boards. The VCOMs are there, because I can see them in Device Manager and I can open them using e.g. Putty. Occasionally, the VCOMs are detected, but I haven't observed any pattern explaining when they would and wouldn't be detected.
Other nrfjprog features (showing board ID, flashing the boards...) work just fine.
I use Win 11, and use the following nrfjprog version:
$ nrfjprog -v nrfjprog version: 10.19.0 external JLinkARM.dll version: 7.80c
Thanks!