Hello,
I am currently working with an nRF5340 configured to operate in High Voltage mode, where the main input supply is 5 V.
Issue description
When the nRF5340 is powered only from the main 5 V input, the cores do not appear to start or run correctly.
However, the device behaves normally when an additional 3.3 V reference is present.
Specifically:
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If 3.3 V is applied to the JTAG VREF pin, the cores start and run normally.
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If a 3.3 V signal is present on a GPIO (UART RX pin), the cores also start and run normally.
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Without either of these conditions, the cores do not seem to run when only the 5 V main supply is applied.
How the core activity is verified
I verify whether the cores are running by:
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Monitoring console UART TX output using an oscilloscope
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Observing the behavior of LEDs connected to GPIO pins
When the issue occurs:
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No UART TX activity is observed
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GPIO-connected LEDs do not toggle or behave as expected
When 3.3 V is present on JTAG VREF or UART RX:
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UART TX output appears correctly
-
GPIO LEDs operate normally
Power supply design
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The power circuit is based on the nRF5340 DK reference design
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The device is intended to run in High Voltage mode with a 5 V main input
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No significant deviation from the DK power topology is intended

Is there a recommended way to verify whether the nRF5340 cores are running correctly without relying on a UART console?
For example:
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Registers that can be safely read over JTAG
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Power / clock / reset status indicators
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Other hardware-visible signals that confirm core execution
thank yon.
