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Need guidance on code modifiaction based on SDK

My customer is modifying the code based on the example provided in the SDK 15.0.0 to suit their project: 

Project file from the SDK under \nRF5_SDK_15.0.0_a53641a\examples\ble_peripheral\ble_app_uart\pca10040\s132\ses

The questions are:

1. how to change pin assignment, for example TX, RX from 6 & 8 to 21 & 22

2. Reduce current consumption from the sample software, original 2.5mA down to 100uA

  2.1 at the same time when receive duty cycle of the receiver reduced, how to change the sending pattern of transmiter

3. how to run 2 profile concurrently, example: combine UART and proximity software together.

Thanks!