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General feedback on hardware design and antenna placement

Dear Community,

I am working on a project where the idea is to build a board that can measure the resistance over a small biosensor. The biosensor will be connected between GND and P0.02. The theory is to apply a small current over the resistor and then measure the resulting voltage with the ADC. I will use a LiPO battery and, a step down voltage regulator and an operational amplifier. I have used the reference design for the nrf52832 and tried to keep that intact as much as possible.

Any general feedback regarding the design would be very helpful and since this is my first time designing with the nrf52832 I might have done some obvious mistakes. All feedback regarding placement, tracing (ie the VDD_P3V3 going under VDD), noise or ground-loops would be appreciated.

Regarding the antenna and antenna placement I am kinda lost. I read the documentation available here on the forum and decided on a chip antenna that according to the datasheet has an impedance of 50 Ohm. I have attached eagle schematic and board files and images.

  

 nRF52832_qfaa.brdnRF52832_qfaa.sch

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