Zigbee Stack interference with TWIM

During development, I am seeing a strange behavior when enabling zigbee. 

When the application's PRJ file does not enable zigbee, I2C functions as expected. The peripherals can be read and responses are received (as shown in the attached picture) 

Without the zigbee/networking processor active, this is what things look like in yellow below:
1. Raising edge I2C transaction started
2. Falling edge I2C transaction completed
The purple  line indicates edges (falling and raising) are a trigger to start an I2C transaction
PRJ.conf (zigbee not enabled)
CONFIG_FPU=y
CONFIG_SERIAL=y
CONFIG_UART_INTERRUPT_DRIVEN=y
CONFIG_EVENTS=y
CONFIG_I2C=y
CONFIG_NEWLIB_LIBC=y
CONFIG_NEWLIB_LIBC_FLOAT_PRINTF=y
CONFIG_AUDIO=y
CONFIG_CMSIS_DSP=y
CONFIG_CMSIS_DSP_TRANSFORM=y
CONFIG_AUDIO_DMIC=y
CONFIG_NRFX_TIMER1=y
CONFIG_MPU_ALLOW_FLASH_WRITE=y
CONFIG_FLASH=y
CONFIG_FLASH_MAP=y
CONFIG_FLASH_PAGE_LAYOUT=y
CONFIG_FLASH_JESD216_API=y
CONFIG_SPI=n
CONFIG_SPI_NOR=n
CONFIG_NORDIC_QSPI_NOR=y
CONFIG_NORDIC_QSPI_NOR_FLASH_LAYOUT_PAGE_SIZE=4096
CONFIG_FILE_SYSTEM=y
CONFIG_FILE_SYSTEM_LITTLEFS=y
#CONFIG_APP_WIPE_STORAGE=y
CONFIG_APP_LITTLEFS_STORAGE_FLASH=y
# CONFIG_LOG=y
# CONFIG_LOG_BACKEND_UART=n
# CONFIG_LOG_MODE_MINIMAL=y
# CONFIG_LOG_DEFAULT_LEVEL=0
CONFIG_HEAP_MEM_POOL_SIZE=8192
CONFIG_REBOOT=y

When Zigbee configurations are enabled (w/o even initializing Zboss) All comms on i2c3 time out.

CONFIG_FPU=y
CONFIG_SERIAL=y
CONFIG_UART_INTERRUPT_DRIVEN=y
CONFIG_EVENTS=y
CONFIG_I2C=y
CONFIG_NEWLIB_LIBC=y
CONFIG_NEWLIB_LIBC_FLOAT_PRINTF=y
CONFIG_AUDIO=y
CONFIG_AUDIO_DMIC=y

CONFIG_HEAP_MEM_POOL_SIZE=32768

CONFIG_ZIGBEE=y
CONFIG_ZIGBEE_APP_UTILS=y
CONFIG_ZIGBEE_ROLE_END_DEVICE=y
# Enable DK LED and Buttons library
CONFIG_DK_LIBRARY=y

# This example requires more workqueue stack
CONFIG_SYSTEM_WORKQUEUE_STACK_SIZE=2048
# Enable API for powering down unused RAM parts
CONFIG_RAM_POWER_DOWN_LIBRARY=y

# Networking
CONFIG_NET_IPV6_MLD=n
CONFIG_NET_IPV6_NBR_CACHE=n
CONFIG_NET_IPV6_RA_RDNSS=n
CONFIG_NET_IP_ADDR_CHECK=n
CONFIG_NET_UDP=n

CONFIG_LOG=y
CONFIG_LOG_DEFAULT_LEVEL=1
CONFIG_IEEE802154_DRIVER_LOG_LEVEL_INF=y

CONFIG_NRF53_SYNC_RTC=n

CONFIG_ASSERT=y
CONFIG_SPIN_VALIDATE=y
CONFIG_LOG_MODE_MINIMAL=n

CONFIG_MAIN_STACK_SIZE=2048

# Use software cryptography on nRF5340
CONFIG_ZIGBEE_USE_SOFTWARE_AES=y

# Networking
CONFIG_MPSL=n


CONFIG_NUM_COOP_PRIORITIES=20
CONFIG_NUM_PREEMPT_PRIORITIES=30
CONFIG_CMSIS_DSP=y
CONFIG_CMSIS_DSP_TRANSFORM=y
CONFIG_AUDIO_DMIC=y
CONFIG_NRFX_TIMER1=y
CONFIG_MPU_ALLOW_FLASH_WRITE=y
CONFIG_FLASH=y
CONFIG_FLASH_MAP=y
CONFIG_FLASH_PAGE_LAYOUT=y
CONFIG_FLASH_JESD216_API=y
CONFIG_SPI=n
CONFIG_SPI_NOR=n
CONFIG_NORDIC_QSPI_NOR=y
CONFIG_NORDIC_QSPI_NOR_FLASH_LAYOUT_PAGE_SIZE=4096
CONFIG_FILE_SYSTEM=y
CONFIG_FILE_SYSTEM_LITTLEFS=y
#CONFIG_APP_WIPE_STORAGE=y
CONFIG_APP_LITTLEFS_STORAGE_FLASH=y
# CONFIG_LOG=y
# CONFIG_LOG_BACKEND_UART=n
# CONFIG_LOG_MODE_MINIMAL=y
# CONFIG_LOG_DEFAULT_LEVEL=0
CONFIG_REBOOT=y

Is there a known interaction between zigbee and I2C that prevents all I2C peripherals from bein used?

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