The SoC nrf5340 I2C channel random failure with Zephyr

We are using a few sensors like (IMU, Barometer ) on one of the I2C lines. All the other sensors gets detected but the IMU and Barometer does not get detected even when the CS and SDA SCL are high. The Pull up resistors (internal) does not make the SDA and SCL high and there is no 3V detected on these. However on turning the pins 43 and 45 High, the SCL and SDA becomes high and the IMU and barometer get detected.

But as the Bluetooth stack is put and activated, the detection again stops. It is arbitrary behaviour of I2C bus that is confusing us. 

Any idea what is happening here?

Schematic-4-5.pdfSchematicSLIM.pdf

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